{"id":8265,"date":"2023-11-06T14:10:46","date_gmt":"2023-11-06T13:10:46","guid":{"rendered":"https:\/\/www.roleca.com\/juniper-juniperus-communis-and-heartburn\/"},"modified":"2026-10-29T09:08:26","modified_gmt":"2026-10-29T08:08:26","slug":"juniper-juniperus-communis-and-heartburn","status":"publish","type":"page","link":"https:\/\/www.roleca.com\/en\/healthy-digestion\/heartburn\/juniper-juniperus-communis-and-heartburn\/","title":{"rendered":"Juniper (Juniperus Communis) and Heartburn"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-14qbdb-0e0ca6127a950559eaa98a66a82d2001\">\n.avia-section.av-14qbdb-0e0ca6127a950559eaa98a66a82d2001{\nbackground-color:var(--green2);\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/www.roleca.com\/wp-content\/uploads\/rolecapharma-sodbrennen_web.jpg), linear-gradient( to bottom, var(--green2), var(--green1) );\nbackground-position:50% 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class='avia_textblock'  itemprop=\"text\" ><h1><strong>Juniper (<em>Juniper Communis<\/em>) and Heartburn<\/strong><\/h1>\n<p>Juniper berries have traditionally been used in various cultures for their potential medicinal properties, including for digestive problems such as <a href=\"https:\/\/www.roleca.com\/en\/healthy-digestion\/heartburn\/\">heartburn<\/a>. The European Medicines Agency (EMA) lists the traditional use of marketed medicinal juniper (<em>Juniper communis<\/em>) for mild gastrointestinal disorders such as dyspepsia and bloating in Poland since 1955 and in Germany since 1986 (1). <\/p>\n<p>Clinical evidence for the efficacy of juniper specifically for heartburn is not easily accessible; however, juniper berries contain compounds such as terpenes and flavonoids that have been studied for their potential anti-inflammatory and digestive properties. Proponents describe that these compounds could relieve heartburn symptoms by reducing inflammation and promoting digestion. <\/p>\n<p>The juniper berries (<em>Juniper communis<\/em>) used to manufacture Roleca contain at least 10 ml\/kg of essential oil, the components of which are listed below with the percentages required by the Ph. Eur. standard:<\/p>\n<ul>\n<li>\u03b1-Pinene (20 to 50%)<\/li>\n<li>Sabinene (maximum 20%)<\/li>\n<li>\u03b2-Pinene (1 to 12%)<\/li>\n<li>\u03b2-Myrcene (1 to 35%)<\/li>\n<li>\u03b1-Phellandrene (maximum 1.0%)<\/li>\n<li>Limonene (2 to 12%)<\/li>\n<li>Terpinen-4-ol (0.5 to 10%)<\/li>\n<li>Bornyl acetate (maximum 2.0%)<\/li>\n<li>\u03b2-Caryophyllene (maximum 7.0%)<\/li>\n<\/ul>\n<p>Other components such as tannins, flavonoids, diterpene acids, aldehydes\/alcohols, and fatty alcohols have also been listed (1, 2).<\/p>\n<p>A study analyzing the essential oil of Pinus koraiensis found that the most effective fraction studied contains many of the same compounds as juniper essential oil, including \u03b1-pinene, \u03b2-pinene, \u03b1-terpineol, and limonene (3). The anti-inflammatory effect of pinenes (one of the most common compounds in juniper oil) is particularly well-documented in both animal (4, 5, 6) and human models (7). The signaling pathways involved in these properties were described in detail in a study on mouse macrophages. It was found that the addition of \u03b1-pinene suppresses inflammatory markers (decreased levels of interleukin-6, tumor necrosis factor-\u03b1, and nitric oxide, inducible nitric oxide synthase, and cyclooxygenase-2) by acting on mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-\u03baB) signaling pathways (8).    <\/p>\n<p>Inflammation of the esophagus, often caused by repeated contact with stomach acid due to GERD, can lead to symptoms such as heartburn. Additionally, certain foods and beverages such as spicy foods, citrus fruits, tomatoes, caffeine, and alcohol can trigger inflammation in the digestive tract and contribute to heartburn symptoms (9). Therefore, reducing inflammation through the use of juniper berry oil may help patients relieve their heartburn.  <\/p>\n<p>Furthermore, heartburn episodes are often associated with persistent esophageal contractions. Juniper oil has been shown to have spasmolytic properties, as it causes relaxation of potassium-induced contractions in rabbit jejunum preparations at concentrations similar to papaverine (2). This provides a further pharmacological basis for its traditional use in intestinal disorders such as dyspepsia and associated heartburn.  <\/p>\n<h1><\/h1>\n<p style=\"font-weight: 400;\">\n<\/div><\/section><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-22lbze-394068518114cb0f6aab8df72f10ad70\">\n#top .flex_column_table.av-equal-height-column-flextable.av-22lbze-394068518114cb0f6aab8df72f10ad70{\nmargin-top:-5px;\nmargin-bottom:0px;\n}\n.flex_column.av-22lbze-394068518114cb0f6aab8df72f10ad70{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-22lbze-394068518114cb0f6aab8df72f10ad70 av_one_fifth  avia-builder-el-5  el_after_av_three_fifth  avia-builder-el-last  flip-mobile av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  '     ><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_2'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-8265'><div class='entry-content-wrapper clearfix'><section  class='av_textblock_section av-lu2pcoye-4e9890f41104c043157c751472e493db '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>References<\/h4>\n<ol>\n<li>European Medicines Agency. final assessment report juniperus communis l pseudo fructus galbulus revision [Internet]. 2023 [cited 2024 Feb 18]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-report\/final-assessment-report-juniperus-communis-l-pseudo-fructus-galbulus-revision-1_en.pdf   <\/li>\n<li>Khan M, Khan AU, Najeeb-Ur-Rehman, Gilani AH. Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders. Journal of Natural Medicines. 2012 Apr;66(2):292\u2013301.   <\/li>\n<li>Yang J, Choi WS, Kim KJ, Eom CD, Park MJ. Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells. Biomolecules. 2021 May 31;11(6):817.   <\/li>\n<li>Santos ES, de Sousa Machado ST, Rodrigues FB, da Silva YA, Matias LCX, Lopes MJP, et al. Potential anti-inflammatory, hypoglycemic, and hypolipidemic activities of alpha-pinene in diabetic rats. Process Biochemistry. 2023 Mar 1;126:80\u20136.   <\/li>\n<li>Santos ES, Abrantes Coelho GL, Saraiva Fontes Loula YK, Saraiva Landim BL, Fernandes Lima CN, Tavares de Sousa Machado S, et al. Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats. Evid Based Complement Alternat Med. 2022;2022:8173307.<\/li>\n<li>Khoshnazar M, Parvardeh S, Bigdeli MR. Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104977.<\/li>\n<li>Rufino AT, Ribeiro M, Judas F, Salgueiro L, Lopes MC, Cavaleiro C, et al. Anti-inflammatory and chondroprotective activity of (+)-\u03b1-pinene: structural and enantiomeric selectivity. J Nat Prod. 2014 Feb 28;77(2):264\u20139.   <\/li>\n<li>Kim DS, Lee HJ, Jeon YD, Han YH, Kee JY, Kim HJ, et al. Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-\u03baB Pathway in Mouse Peritoneal Macrophages. Am J Chin Med. 2015;43(4):731\u201342.  <\/li>\n<li>Oustamanolakis P, Tack J. Dyspepsia: organic versus functional. J Clin Gastroenterol. 2012 Mar;46(3):175\u201390  <\/li>\n<\/ol>\n<\/div><\/section><\/p>\n[av_section min_height='' min_height_pc='25' min_height_px='500px' padding='default' custom_margin='0px' custom_margin_sync='true' color='main_color' background='bg_color' custom_bg='var(--green1)' background_gradient_color1='var(--green100)' background_gradient_color2='var(--green1)' background_gradient_direction='vertical' src='' attachment='' attachment_size='' attach='scroll' position='bottom right' repeat='no-repeat' video='' video_ratio='16:9' overlay_opacity='0.5' overlay_color='' overlay_pattern='' overlay_custom_pattern='' shadow='no-border-styling' bottom_border='no-border-styling' bottom_border_diagonal_color='#333333' bottom_border_diagonal_direction='' bottom_border_style='' custom_arrow_bg='' id='' custom_class='column_flex_reorder' aria_label='' av_element_hidden_in_editor='0' av_uid='av-9ypwv']\n\n[av_one_full first min_height='av-equal-height-column' vertical_alignment='av-align-top' space='' row_boxshadow_color='' row_boxshadow_width='10' margin='0px' margin_sync='true' mobile_breaking='av-break-at-tablet' border='' border_color='' radius='0px' radius_sync='true' padding='0px' padding_sync='true' column_boxshadow_color='' column_boxshadow_width='10' background='bg_color' background_color='' background_gradient_color1='' background_gradient_color2='' background_gradient_direction='vertical' src='' attachment='' attachment_size='' background_position='top left' background_repeat='no-repeat' highlight_size='1.1' animation='' link='' linktarget='' link_hover='' title_attr='' alt_attr='' mobile_display='' id='' custom_class='flip-mobile' aria_label='' av_uid='av-sifpz']\n\n[av_textblock size='' av-medium-font-size='' av-small-font-size='' av-mini-font-size='' font_color='' color='' id='' custom_class='' av_uid='av-kuzes252' admin_preview_bg='']\n<h3>Learn more about the following topics<\/h3>\n[\/av_textblock]\n\n[\/av_one_full][av_one_third first min_height='av-equal-height-column' vertical_alignment='av-align-top' space='' row_boxshadow_color='#757575' row_boxshadow_width='10' margin='0px' margin_sync='true' mobile_breaking='av-break-at-tablet' border='' border_color='' radius='0px' radius_sync='true' padding='0px' padding_sync='true' column_boxshadow_color='' column_boxshadow_width='10' background='bg_color' background_color='' background_gradient_color1='' background_gradient_color2='' background_gradient_direction='vertical' src='' attachment='' attachment_size='' background_position='top left' background_repeat='no-repeat' highlight_size='1.1' animation='' link='' linktarget='' link_hover='' title_attr='' alt_attr='' mobile_display='' id='' custom_class='img_rahmen' aria_label='' av_uid='av-sifpz-5']\n\n[av_image_txt src=\"https:\/\/www.roleca.com\/wp-content\/uploads\/169_ROLECA_Verdauungsbeschwerden.jpg\" attachment=\"2213\" attachment_size=\"full\" copyright=\"\" caption=\"yes\" styling=\"\" align=\"center\" font_size=\"\" overlay_opacity=\"0.4\" overlay_color=\"#000000\" overlay_text_color=\"#ffffff\" animation=\"no-animation\" hover=\"\" appearance=\"\" link=\"\" target=\"\" title_attr=\"\" alt_attr=\"bl\u00e4hungen und v\u00f6llegef\u00fchl\" lazy_loading=\"disabled\" id=\"\" custom_class=\"\" av_element_hidden_in_editor=\"0\" av_uid=\"av-kuza838l\" admin_preview_bg=\"\"]\n<h4>Bloating and Fullness<\/h4>\nIn a survey, 7 out of 10 respondents reported having suffered from digestive issues in the past 12 months. Bloating and fullness are often leading symptoms that are uncomfortable for those affected. You can find more detailed information and a suggested treatment here.  \n\n<span class=\"rpbutton\"><a href=\"https:\/\/www.roleca.com\/verdauung\/verdauungsprobleme\/#haeufigesymptomeverdauungsprobleme\">Learn More<\/a><\/span>\n[\/av_image_txt]\n\n[\/av_one_third][av_one_third min_height='av-equal-height-column' vertical_alignment='av-align-top' space='' row_boxshadow_color='#757575' row_boxshadow_width='10' margin='0px' margin_sync='true' mobile_breaking='av-break-at-tablet' border='' border_color='' radius='0px' radius_sync='true' padding='0px' padding_sync='true' column_boxshadow_color='' column_boxshadow_width='10' background='bg_color' background_color='' background_gradient_color1='' background_gradient_color2='' background_gradient_direction='vertical' src='' attachment='' attachment_size='' background_position='top left' background_repeat='no-repeat' highlight_size='1.1' animation='' link='' linktarget='' link_hover='' title_attr='' alt_attr='' mobile_display='' id='' custom_class='img_rahmen' aria_label='' av_uid='av-sifpz-4']\n\n[av_image_txt src=\"https:\/\/www.roleca.com\/wp-content\/uploads\/rolecapharma_21968563.jpg\" attachment=\"2199\" attachment_size=\"full\" copyright=\"\" caption=\"yes\" styling=\"\" align=\"center\" font_size=\"\" overlay_opacity=\"0.4\" overlay_color=\"#000000\" overlay_text_color=\"#ffffff\" animation=\"no-animation\" hover=\"\" appearance=\"\" link=\"\" target=\"\" title_attr=\"\" alt_attr=\"darmmirkobiom\" img_scrset=\"\" lazy_loading=\"disabled\" id=\"\" custom_class=\"\" template_class=\"\" av_element_hidden_in_editor=\"0\" av_uid=\"av-kuza838l-3\" sc_version=\"1.0\" admin_preview_bg=\"\"]\n<h4>The Gut Microbiome<\/h4>\nCentral functions such as breaking down food, providing essential vitamins and nutrients, and protecting against pathogens and strengthening the immune system are just an initial indication of how important the gut microbiome is for holistic health.\n\n<span class=\"rpbutton\"><a href=\"https:\/\/www.roleca.com\/verdauung\/mikrobiom\/\">Learn More<\/a><\/span>\n[\/av_image_txt]\n\n[\/av_one_third][av_one_third min_height='av-equal-height-column' vertical_alignment='av-align-top' space='' row_boxshadow_color='#757575' row_boxshadow_width='10' margin='0px' margin_sync='true' mobile_breaking='av-break-at-tablet' border='' border_color='' radius='0px' radius_sync='true' padding='0px' padding_sync='true' column_boxshadow_color='' column_boxshadow_width='10' background='bg_color' background_color='' background_gradient_color1='' background_gradient_color2='' background_gradient_direction='vertical' src='' attachment='' attachment_size='' background_position='top left' background_repeat='no-repeat' highlight_size='1.1' animation='' link='' linktarget='' link_hover='' title_attr='' alt_attr='' mobile_display='' id='' custom_class='img_rahmen' aria_label='' av_uid='av-sifpz-2']\n\n[av_image_txt src=\"https:\/\/www.roleca.com\/wp-content\/uploads\/roleca_laxan_brausetablette_anwendung_web.jpg\" attachment=\"3909\" attachment_size=\"full\" copyright=\"\" caption=\"yes\" styling=\"\" align=\"center\" font_size=\"\" overlay_opacity=\"0.4\" overlay_color=\"#000000\" overlay_text_color=\"#ffffff\" animation=\"no-animation\" hover=\"\" appearance=\"\" link=\"\" target=\"\" title_attr=\"\" alt_attr=\"tr\u00e4ger darm ankurbeln\" img_scrset=\"\" lazy_loading=\"disabled\" id=\"\" custom_class=\"\" template_class=\"\" av_element_hidden_in_editor=\"0\" av_uid=\"av-kuza838l-1\" sc_version=\"1.0\" admin_preview_bg=\"\"]\n<h4>Roleca\u00ae Macrogol Effervescent Tablets<\/h4>\nStaying active is a commonly heard piece of advice for general health. Movement is beneficial and contributes to a healthy lifestyle, especially outdoors. Our gut also benefits from a change of pace from long periods of sitting. But what to do when the gut is sluggish?\n\n<span class=\"rpbutton\"><a href=\"https:\/\/www.roleca.com\/produkte\/macrogol\/\">Learn More<\/a><\/span>\n[\/av_image_txt]\n\n[\/av_one_third][\/av_section]\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4k5ctb-8d675554f5592d95607770bc3255131b\">\n.avia-section.av-4k5ctb-8d675554f5592d95607770bc3255131b{\nbackground-color:var(--green1);\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-4k5ctb-8d675554f5592d95607770bc3255131b main_color avia-section-default avia-no-border-styling  avia-builder-el-8  el_after_av_postcontent  avia-builder-el-last  column_flex_reorder avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-8265'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-25s7sv-653996436e5336df235d28ccecbd44e6 sc-av_one_full av-break-at-tablet-flextable av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-25s7sv-653996436e5336df235d28ccecbd44e6\">\n.flex_column.av-25s7sv-653996436e5336df235d28ccecbd44e6{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-25s7sv-653996436e5336df235d28ccecbd44e6 av_one_full  avia-builder-el-9  avia-builder-el-no-sibling  first av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  '     ><\/div><\/div><!--close column table wrapper. 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